7WJ5

Cryo-EM structure of human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand binding specificity

Summary for 7WJ5

• Entry DOI: 10.2210/pdb7wj5/pdb
• EMDB information: 32543
• Related PRD ID: PRD_001216
• Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: gpcr, agonist, heterotrimeric g-protein, camp, membrane protein, membrane protein-immune system complex, membrane protein/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 176136.43

Authors

Heo, Y.S.,Yoon, E.J.,Jeon, Y.E.,Yun, J.-H.,Ishimoto, N.,Woo, H.,Park, S.Y.,Song, J.,Lee, W.T. (deposition date: 2022-01-05, release date: 2022-07-13)

• Primary citation: Heo, Y.,Yoon, E.,Jeon, Y.E.,Yun, J.H.,Ishimoto, N.,Woo, H.,Park, S.Y.,Song, J.J.,Lee, W.; Cryo-EM structure of the human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand-binding specificity.; Elife, 11:-, 2022; PubMed: 35446253; DOI: 10.7554/eLife.76823

Experimental method

ELECTRON MICROSCOPY (3.72 Å)