7WID

Crystal structure of Staphylococcus aureus ClpP in complex with ZG180

Summary for 7WID

Entry DOI	10.2210/pdb7wid/pdb
Descriptor	ATP-dependent Clp protease proteolytic subunit, (6S,9aS)-6-[(2S)-butan-2-yl]-8-(naphthalen-1-ylmethyl)-4,7-bis(oxidanylidene)-N-[4,4,4-tris(fluoranyl)butyl]-3,6,9,9a-tetrahydro-2H-pyrazino[1,2-a]pyrimidine-1-carboxamide, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	protease, hydrolase
Biological source	Staphylococcus aureus
Total number of polymer chains	14
Total formula weight	310978.18
Authors	Wei, B.Y.,Gan, J.H.,Yang, C.-G. (deposition date: 2022-01-03, release date: 2022-11-16, Last modification date: 2023-11-29)
Primary citation	Wei, B.,Zhang, T.,Wang, P.,Pan, Y.,Li, J.,Chen, W.,Zhang, M.,Ji, Q.,Wu, W.,Lan, L.,Gan, J.,Yang, C.G. Anti-infective therapy using species-specific activators of Staphylococcus aureus ClpP. Nat Commun, 13:6909-6909, 2022 Cited by PubMed: 36376309 DOI: 10.1038/s41467-022-34753-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation