7WGP
X-ray structure of human PPAR gamma ligand binding domain-fenofibric acid co-crystals obtained by co-crystallization
Summary for 7WGP
Entry DOI | 10.2210/pdb7wgp/pdb |
Descriptor | Isoform 1 of Peroxisome proliferator-activated receptor gamma, 15-meric peptide from Nuclear receptor coactivator 1, 2-[4-(4-chlorobenzene-1-carbonyl)phenoxy]-2-methylpropanoic acid (3 entities in total) |
Functional Keywords | nuclear receptor, protein-ligand complex, ppar, transcription |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 34667.43 |
Authors | Kamata, S.,Honda, A.,Akahane, M.,Machida, Y.,Uchii, K.,Shiiyama, Y.,Masuda, R.,Oyama, T.,Ishii, I. (deposition date: 2021-12-28, release date: 2022-05-25, Last modification date: 2023-11-29) |
Primary citation | Honda, A.,Kamata, S.,Akahane, M.,Machida, Y.,Uchii, K.,Shiiyama, Y.,Habu, Y.,Miyawaki, S.,Kaneko, C.,Oyama, T.,Ishii, I. Functional and Structural Insights into Human PPAR alpha / delta / gamma Subtype Selectivity of Bezafibrate, Fenofibric Acid, and Pemafibrate. Int J Mol Sci, 23:-, 2022 Cited by PubMed: 35563117DOI: 10.3390/ijms23094726 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.53 Å) |
Structure validation
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