7WCX

Crystal structure of FGFR4(V550M) kinase domain with 7v

7WCX の概要

• エントリーDOI: 10.2210/pdb7wcx/pdb
• 分子名称: Fibroblast growth factor receptor 4, ~{N}-[2-[[5-[(1~{R})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1~{H}-indazol-3-yl]amino]-3-fluoranyl-5-(4-morpholin-4-ylpiperidin-1-yl)phenyl]propanamide, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: kinase, inhibitor, structural protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35581.72

構造登録者

Chen, X.J.,Lin, Q.M.,Dai, S.Y.,Chen, Y.H. (登録日: 2021-12-20, 公開日: 2022-03-30, 最終更新日: 2023-11-29)

• 主引用文献: Shao, M.,Chen, X.,Yang, F.,Song, X.,Zhou, Y.,Lin, Q.,Fu, Y.,Ortega, R.,Lin, X.,Tu, Z.,Patterson, A.V.,Smaill, J.B.,Chen, Y.,Lu, X.; Design, Synthesis, and Biological Evaluation of Aminoindazole Derivatives as Highly Selective Covalent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR4.; J.Med.Chem., 65:5113-5133, 2022; PubMed: 35271262; DOI: 10.1021/acs.jmedchem.2c00096

実験手法

X-RAY DIFFRACTION (2.175 Å)