7W9T

Cryo-EM structure of human Nav1.7(E406K) in complex with auxiliary beta subunits, huwentoxin-IV and saxitoxin (S6IV alpha helix conformer)

7W9T の概要

• エントリーDOI: 10.2210/pdb7w9t/pdb
• EMDBエントリー: 32372
• 分子名称: Sodium channel protein type 9 subunit alpha, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... (11 entities in total)
• 機能のキーワード: voltage gated sodium channel, membrane protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 298626.53

構造登録者

Yan, N.,Huang, G.,Liu, D.,Wei, P. (登録日: 2021-12-10, 公開日: 2022-05-25)

• 主引用文献: Huang, G.,Liu, D.,Wang, W.,Wu, Q.,Chen, J.,Pan, X.,Shen, H.,Yan, N.; High-resolution structures of human Na v 1.7 reveal gating modulation through alpha-pi helical transition of S6 IV.; Cell Rep, 39:110735-110735, 2022; PubMed: 35476982; DOI: 10.1016/j.celrep.2022.110735

実験手法

ELECTRON MICROSCOPY (3 Å)