7W41

Crystal Structure of Human Gastrin Releasing Peptide Receptor in complex with the antagonist PD176252

7W41 の概要

• エントリーDOI: 10.2210/pdb7w41/pdb
• 分子名称: Gastrin-releasing peptide receptor,GlgA glycogen synthase, (2S)-3-(1H-indol-3-yl)-N-[[1-(5-methoxypyridin-2-yl)cyclohexyl]methyl]-2-methyl-2-[(4-nitrophenyl)carbamoylamino]propanamide (2 entities in total)
• 機能のキーワード: gpcr, gastrin releasing peptide receptor, membrane protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 54959.42

構造登録者

Peng, S.,Zhan, Y.,Zhang, H. (登録日: 2021-11-26, 公開日: 2023-02-22, 最終更新日: 2023-11-29)

• 主引用文献: Peng, S.,Zhan, Y.,Zhang, D.,Ren, L.,Chen, A.,Chen, Z.F.,Zhang, H.; Structures of human gastrin-releasing peptide receptors bound to antagonist and agonist for cancer and itch therapy.; Proc.Natl.Acad.Sci.USA, 120:e2216230120-e2216230120, 2023; PubMed: 36724251; DOI: 10.1073/pnas.2216230120

実験手法

X-RAY DIFFRACTION (2.952 Å)