7W1M

Cryo-EM structure of human cohesin-CTCF-DNA complex

Summary for 7W1M

• Entry DOI: 10.2210/pdb7w1m/pdb
• EMDB information: 32252
• Descriptor: Structural maintenance of chromosomes protein 1A, BERYLLIUM TRIFLUORIDE ION, ZINC ION, ... (11 entities in total)
• Functional Keywords: cohesin, nipbl, ctcf, dna, chromosome folding, topologically associating domain, chromatin loops, dna loop extrusion, sister chromatid cohesion, complex, atpase, heat repeat protein, dna binding protein, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 826702.61

Authors

Shi, Z.B.,Bai, X.C.,Yu, H. (deposition date: 2021-11-19, release date: 2023-05-31, Last modification date: 2023-12-13)

• Primary citation: Zhang, H.,Shi, Z.,Banigan, E.J.,Kim, Y.,Yu, H.,Bai, X.C.,Finkelstein, I.J.; CTCF and R-loops are boundaries of cohesin-mediated DNA looping.; Mol.Cell, 83:2856-2871.e8, 2023; PubMed: 37536339; DOI: 10.1016/j.molcel.2023.07.006

Experimental method

ELECTRON MICROSCOPY (6.5 Å)