7VXG

Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor TK-453

Summary for 7VXG

• Entry DOI: 10.2210/pdb7vxg/pdb
• Descriptor: Tyrosine-protein phosphatase non-receptor type 11, 6-[4-(aminomethyl)-4-methyl-piperidin-1-yl]-3-[2,3-bis(chloranyl)phenyl]sulfanyl-pyrazin-2-amine (3 entities in total)
• Functional Keywords: protein tyrosine phosphatase, shp2, inhibitor, complex, antitumor protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 242933.55

Authors

Li, T.H.,Guo, H.T.,Ji, X.Y. (deposition date: 2021-11-12, release date: 2022-03-23, Last modification date: 2023-11-29)

• Primary citation: Wang, M.,Li, T.,Ouyang, Z.,Tang, K.,Zhu, Y.,Song, C.,Sun, H.,Yu, B.,Ji, X.,Sun, Y.; SHP2 allosteric inhibitor TK-453 alleviates psoriasis-like skin inflammation in mice via inhibition of IL-23/Th17 axis.; Iscience, 25:104009-104009, 2022; PubMed: 35310939; DOI: 10.1016/j.isci.2022.104009

Experimental method

X-RAY DIFFRACTION (2.1 Å)