7VXG
Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor TK-453
Summary for 7VXG
Entry DOI | 10.2210/pdb7vxg/pdb |
Descriptor | Tyrosine-protein phosphatase non-receptor type 11, 6-[4-(aminomethyl)-4-methyl-piperidin-1-yl]-3-[2,3-bis(chloranyl)phenyl]sulfanyl-pyrazin-2-amine (3 entities in total) |
Functional Keywords | protein tyrosine phosphatase, shp2, inhibitor, complex, antitumor protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 242933.55 |
Authors | |
Primary citation | Wang, M.,Li, T.,Ouyang, Z.,Tang, K.,Zhu, Y.,Song, C.,Sun, H.,Yu, B.,Ji, X.,Sun, Y. SHP2 allosteric inhibitor TK-453 alleviates psoriasis-like skin inflammation in mice via inhibition of IL-23/Th17 axis. Iscience, 25:104009-104009, 2022 Cited by PubMed: 35310939DOI: 10.1016/j.isci.2022.104009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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