7VXG
Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor TK-453
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Tyrosine-protein phosphatase non-receptor type 11 | polymer | 526 | 60335.0 | 4 | UniProt (Q06124) Pfam (PF00017) Pfam (PF00102) | Homo sapiens (human) | Protein-tyrosine phosphatase 1D,PTP-1D,Protein-tyrosine phosphatase 2C,PTP-2C,SH-PTP2,SHP-2,Shp2,SH-PTP3 |
| 2 | E, F, G, H (A, B, C, D) | 6-[4-(aminomethyl)-4-methyl-piperidin-1-yl]-3-[2,3-bis(chloranyl)phenyl]sulfanyl-pyrazin-2-amine | non-polymer | 398.4 | 4 | Chemie (83Q) | |||
| 3 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 380 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 525 (UniProt: Q06124)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 241340.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1593.4 | |
| All* | Total formula weight | 242933.6 |
