7VPU

Crystal structure of the ligand-binding domain of L. thermotolerans Upc2 in complex with ergosterol

Summary for 7VPU

Entry DOI	10.2210/pdb7vpu/pdb
Descriptor	Sterol uptake control protein 2 (Upc2), ERGOSTEROL (2 entities in total)
Functional Keywords	ergosterol, transcription factor, ligand-binding, zinc finger, transcription
Biological source	Lachancea thermotolerans CBS 6340
Total number of polymer chains	4
Total formula weight	150055.97
Authors	Tan, L.,Im, Y.J. (deposition date: 2021-10-18, release date: 2022-08-24, Last modification date: 2023-11-29)
Primary citation	Tan, L.,Chen, L.,Yang, H.,Jin, B.,Kim, G.,Im, Y.J. Structural basis for activation of fungal sterol receptor Upc2 and azole resistance. Nat.Chem.Biol., 18:1253-1262, 2022 Cited by PubMed: 36229681 DOI: 10.1038/s41589-022-01117-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.59 Å)

Structure validation