7VM6

Crystal structure of uPA in complex with 6-amidino-2-naphthol

Summary for 7VM6

• Entry DOI: 10.2210/pdb7vm6/pdb
• Descriptor: Urokinase-type plasminogen activator chain B, 6-oxidanylnaphthalene-2-carboximidamide, SULFATE ION, ... (5 entities in total)
• Functional Keywords: upa, serine protease, 6-amidino-2-naphthol, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 28406.27

Authors

Jiang, L.G.,Huang, M.D. (deposition date: 2021-10-07, release date: 2022-10-12, Last modification date: 2023-11-29)

• Primary citation: Zhou, Y.,Wu, J.,Xue, G.,Li, J.,Jiang, L.,Huang, M.; Structural study of the uPA-nafamostat complex reveals a covalent inhibitory mechanism of nafamostat.; Biophys.J., 121:3940-3949, 2022; PubMed: 36039386; DOI: 10.1016/j.bpj.2022.08.034

Experimental method

X-RAY DIFFRACTION (1.79 Å)