7VKO

Crystal structure of TrkA kinase with repotrectinib

7VKO の概要

• エントリーDOI: 10.2210/pdb7vko/pdb
• 分子名称: Tyrosine-protein kinase receptor, Repotrectinib, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: trk, ntrk, macrocyclic inhibitor, drug resistance, repotrectinib, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38071.46

構造登録者

Murray, B.W.,Rogers, E.,Zhai, D.,Deng, W.,Chen, X.,Sprengeler, P.A.,Zhang, X.,Graber, A.,Reich, S.H.,Stopatschinskaja, S.,Solomon, B.,Besse, B.,Drilon, A. (登録日: 2021-09-30, 公開日: 2021-10-13, 最終更新日: 2023-11-29)

• 主引用文献: Murray, B.W.,Rogers, E.,Zhai, D.,Deng, W.,Chen, X.,Sprengeler, P.A.,Zhang, X.,Graber, A.,Reich, S.H.,Stopatschinskaja, S.,Solomon, B.,Besse, B.,Drilon, A.; Molecular Characteristics of Repotrectinib That Enable Potent Inhibition of TRK Fusion Proteins and Resistant Mutations.; Mol.Cancer Ther., 20:2446-2456, 2021; PubMed: 34625502; DOI: 10.1158/1535-7163.MCT-21-0632

実験手法

X-RAY DIFFRACTION (2.9 Å)