7VKM
Crystal structure of TrkA (G595R) kinase domain
Summary for 7VKM
Entry DOI | 10.2210/pdb7vkm/pdb |
Descriptor | Tyrosine-protein kinase receptor (2 entities in total) |
Functional Keywords | trk, ntrk, macrocyclic inhibitor, drug resistance, repotrectinib, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 37335.92 |
Authors | Murray, B.W.,Rogers, E.,Zhai, D.,Deng, W.,Chen, X.,Sprengeler, P.A.,Zhang, X.,Graber, A.,Reich, S.H.,Stopatschinskaja, S.,Solomon, B.,Besse, B.,Drilon, A. (deposition date: 2021-09-30, release date: 2021-10-13, Last modification date: 2023-11-29) |
Primary citation | Murray, B.W.,Rogers, E.,Zhai, D.,Deng, W.,Chen, X.,Sprengeler, P.A.,Zhang, X.,Graber, A.,Reich, S.H.,Stopatschinskaja, S.,Solomon, B.,Besse, B.,Drilon, A. Molecular Characteristics of Repotrectinib That Enable Potent Inhibition of TRK Fusion Proteins and Resistant Mutations. Mol.Cancer Ther., 20:2446-2456, 2021 Cited by PubMed: 34625502DOI: 10.1158/1535-7163.MCT-21-0632 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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