7VIC

The crystal structure of SARS-CoV-2 3C-like protease in complex with a traditional Chinese Medicine Inhibitors

Summary for 7VIC

• Entry DOI: 10.2210/pdb7vic/pdb
• Descriptor: 3C-like proteinase, (1beta,6beta,7beta,8alpha,9beta,10alpha,13alpha,14R,16beta)-1,6,7,14-tetrahydroxy-7,20-epoxykauran-15-one (3 entities in total)
• Functional Keywords: sars-cov-2, inhibitor, 3clpro, virus, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
• Total number of polymer chains: 1
• Total formula weight: 34192.00

Authors

Zhong, B.,Chen, B.,Zhou, H.,Sun, L. (deposition date: 2021-09-26, release date: 2022-03-30, Last modification date: 2023-11-29)

• Primary citation: Zhong, B.,Peng, W.,Du, S.,Chen, B.,Feng, Y.,Hu, X.,Lai, Q.,Liu, S.,Zhou, Z.W.,Fang, P.,Wu, Y.,Gao, F.,Zhou, H.,Sun, L.; Oridonin Inhibits SARS-CoV-2 by Targeting Its 3C-Like Protease.; Small Sci, 2:2100124-2100124, 2022; PubMed: 35600064; DOI: 10.1002/smsc.202100124

Experimental method

X-RAY DIFFRACTION (2.1 Å)