7VE2
Crystal Structure of Lopinavir bound Plasmepsin II (PMII) from Plasmodium falciparum
Summary for 7VE2
Entry DOI | 10.2210/pdb7ve2/pdb |
Descriptor | Plasmepsin II, N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE (3 entities in total) |
Functional Keywords | inhibitor, protease, peptidomimetic, hiv-1 protease inhibitor, peptidase, hemoglobin degrader, hydrolase |
Biological source | Plasmodium falciparum (isolate 3D7) |
Total number of polymer chains | 1 |
Total formula weight | 38972.48 |
Authors | Mishra, V.,Rathore, I.,Bhaumik, P. (deposition date: 2021-09-07, release date: 2023-02-01, Last modification date: 2024-10-16) |
Primary citation | Mishra, V.,Deshmukh, A.,Rathore, I.,Chakraborty, S.,Patankar, S.,Gustchina, A.,Wlodawer, A.,Yada, R.Y.,Bhaumik, P. Inhibition of Plasmodium falciparum plasmepsins by drugs targeting HIV-1 protease: A way forward for antimalarial drug discovery. Curr Res Struct Biol, 7:100128-100128, 2024 Cited by PubMed: 38304146DOI: 10.1016/j.crstbi.2024.100128 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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