7VDU

The structure of cyclin-dependent kinase 2 (CDK2) in complex with Compound 1

Summary for 7VDU

Entry DOI	10.2210/pdb7vdu/pdb
Descriptor	Cyclin-dependent kinase 2, [1-[3-fluoranyl-4-[(2-piperidin-4-yloxy-1,6-naphthyridin-7-yl)amino]phenyl]pyrazol-3-yl]methanol (3 entities in total)
Functional Keywords	transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	34582.09
Authors	Malojcic, G.,Clugston, S.L.,Daniels, M.,Harmange, J.C.,Ledeborer, M. (deposition date: 2021-09-07, release date: 2022-03-09, Last modification date: 2023-11-29)
Primary citation	Daniels, M.H.,Malojcic, G.,Clugston, S.L.,Williams, B.,Coeffet-Le Gal, M.,Pan-Zhou, X.R.,Venkatachalan, S.,Harmange, J.C.,Ledeboer, M. Discovery and Optimization of Highly Selective Inhibitors of CDK5. J.Med.Chem., 65:3575-3596, 2022 Cited by PubMed: 35143203 DOI: 10.1021/acs.jmedchem.1c02069 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.53 Å)

Structure validation