7VDQ

The structure of cyclin-dependent kinase 5 (CDK5) in complex with p25 and Compound 7

7VDQ の概要

• エントリーDOI: 10.2210/pdb7vdq/pdb
• 分子名称: Cyclin-dependent-like kinase 5, Cyclin-dependent kinase 5 activator 1, p25, 2-[[7-[[2-fluoranyl-4-[3-(hydroxymethyl)pyrazol-1-yl]phenyl]amino]-1,6-naphthyridin-2-yl]-(1-methylpiperidin-4-yl)amino]ethanoic acid, ... (4 entities in total)
• 機能のキーワード: cdk5, p25, transferase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 114287.53

構造登録者

Malojcic, G.,Clugston, S.L.,Daniels, M.,Harmange, J.C.,Ledeborer, M. (登録日: 2021-09-07, 公開日: 2022-03-09, 最終更新日: 2023-11-29)

• 主引用文献: Daniels, M.H.,Malojcic, G.,Clugston, S.L.,Williams, B.,Coeffet-Le Gal, M.,Pan-Zhou, X.R.,Venkatachalan, S.,Harmange, J.C.,Ledeboer, M.; Discovery and Optimization of Highly Selective Inhibitors of CDK5.; J.Med.Chem., 65:3575-3596, 2022; PubMed: 35143203; DOI: 10.1021/acs.jmedchem.1c02069

実験手法

X-RAY DIFFRACTION (2.91 Å)