7VD4
Crystal structure of BPTF-BRD with ligand TP248 bound
Summary for 7VD4
Entry DOI | 10.2210/pdb7vd4/pdb |
Descriptor | Nucleosome-remodeling factor subunit BPTF, 6-[4-[3-(dimethylamino)propoxy]phenyl]-N-methyl-2-methylsulfonyl-pyrimidin-4-amine (3 entities in total) |
Functional Keywords | bptf bromodomain, lysine acetylation, small-molecule inhibitor, biosynthetic protein, antitumor protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 13750.75 |
Authors | |
Primary citation | Lu, H.,Lu, T.,Zu, S.,Duan, Z.,Guang, Y.,Li, Q.,Ma, J.,Chen, D.,Li, B.,Lu, W.,Jiang, H.,Luo, C.,Ye, D.,Chen, K.,Lin, H. Discovery of a highly potent CECR2 bromodomain inhibitor with 7H-pyrrolo[2,3-d] pyrimidine scaffold. Bioorg.Chem., 123:105768-105768, 2022 Cited by PubMed: 35378372DOI: 10.1016/j.bioorg.2022.105768 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85659146555 Å) |
Structure validation
Download full validation report