7VC2

Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in Complex with inhibitor L96 and L-proline in space group P21

7VC2 の概要

• エントリーDOI: 10.2210/pdb7vc2/pdb
• 分子名称: Prolyl-tRNA synthetase (ProRS), 4-[(3S)-3-cyano-3-cyclopropyl-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(5-methoxypyridin-3-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, PROLINE, ... (6 entities in total)
• 機能のキーワード: protein translation, inhibitor, prs, atp pocket, ligase, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• 由来する生物種: Toxoplasma gondii
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 117884.12

構造登録者

Yogavel, M.,Malhotra, N.,Sharma, A. (登録日: 2021-09-01, 公開日: 2022-09-07, 最終更新日: 2023-11-29)

• 主引用文献: Yogavel, M.,Bougdour, A.,Mishra, S.,Malhotra, N.,Chhibber-Goel, J.,Bellini, V.,Harlos, K.,Laleu, B.,Hakimi, M.A.,Sharma, A.; Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.; Plos Pathog., 19:e1011124-e1011124, 2023; PubMed: 36854028; DOI: 10.1371/journal.ppat.1011124

実験手法

X-RAY DIFFRACTION (2.096 Å)