7VBT

Crystal structure of RIOK2 in complex with CQ211

7VBT の概要

• エントリーDOI: 10.2210/pdb7vbt/pdb
• 分子名称: Serine/threonine-protein kinase RIO2, 8-(6-methoxypyridin-3-yl)-1-[4-piperazin-1-yl-3-(trifluoromethyl)phenyl]-5H-[1,2,3]triazolo[4,5-c]quinolin-4-one (3 entities in total)
• 機能のキーワード: riok2, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 75148.01

構造登録者

Zhu, C.,Zhang, Z.M. (登録日: 2021-09-01, 公開日: 2022-07-06, 最終更新日: 2023-11-29)

• 主引用文献: Ouyang, Y.,Si, H.,Zhu, C.,Zhong, L.,Ma, H.,Li, Z.,Xiong, H.,Liu, T.,Liu, Z.,Zhang, Z.,Zhang, Z.M.,Cai, Q.; Discovery of 8-(6-Methoxypyridin-3-yl)-1-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)-1,5-dihydro- 4H -[1,2,3]triazolo[4,5- c ]quinolin-4-one (CQ211) as a Highly Potent and Selective RIOK2 Inhibitor.; J.Med.Chem., 65:7833-7842, 2022; PubMed: 35584513; DOI: 10.1021/acs.jmedchem.2c00271

実験手法

X-RAY DIFFRACTION (2.54001480108 Å)