7V5N

Crystal structure of Fab fragment of bevacizumab bound to DNA aptamer

Summary for 7V5N

• Entry DOI: 10.2210/pdb7v5n/pdb
• Descriptor: bevacizumab fab light chain, bevacizumab fab heavy chain, DNA (5'-D(*GP*CP*GP*GP*TP*TP*GP*GP*TP*GP*GP*TP*AP*GP*TP*TP*AP*CP*GP*TP*TP*CP*GP*C)-3'), ... (7 entities in total)
• Functional Keywords: antibody, dna complex, dna binding protein, immune system-dna complex, immune system/dna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 113354.71

Authors

Hishiki, A.,Tong, J.,Todoroki, K.,Hashimoto, H. (deposition date: 2021-08-17, release date: 2022-02-02, Last modification date: 2023-11-29)

• Primary citation: Saito, T.,Shimizu, Y.,Tsukakoshi, K.,Abe, K.,Lee, J.,Ueno, K.,Asano, R.,Jones, B.V.,Yamada, T.,Nakano, T.,Tong, J.,Hishiki, A.,Hara, K.,Hashimoto, H.,Sode, K.,Toyo'oka, T.,Todoroki, K.,Ikebukuro, K.; Development of a DNA aptamer that binds to the complementarity-determining region of therapeutic monoclonal antibody and affinity improvement induced by pH-change for sensitive detection.; Biosens.Bioelectron., 203:114027-114027, 2022; PubMed: 35114463; DOI: 10.1016/j.bios.2022.114027

Experimental method

X-RAY DIFFRACTION (1.7 Å)