7V5N

Crystal structure of Fab fragment of bevacizumab bound to DNA aptamer

7V5N の概要

• エントリーDOI: 10.2210/pdb7v5n/pdb
• 分子名称: bevacizumab fab light chain, bevacizumab fab heavy chain, DNA (5'-D(*GP*CP*GP*GP*TP*TP*GP*GP*TP*GP*GP*TP*AP*GP*TP*TP*AP*CP*GP*TP*TP*CP*GP*C)-3'), ... (7 entities in total)
• 機能のキーワード: antibody, dna complex, dna binding protein, immune system-dna complex, immune system/dna
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 113354.71

構造登録者

Hishiki, A.,Tong, J.,Todoroki, K.,Hashimoto, H. (登録日: 2021-08-17, 公開日: 2022-02-02, 最終更新日: 2023-11-29)

• 主引用文献: Saito, T.,Shimizu, Y.,Tsukakoshi, K.,Abe, K.,Lee, J.,Ueno, K.,Asano, R.,Jones, B.V.,Yamada, T.,Nakano, T.,Tong, J.,Hishiki, A.,Hara, K.,Hashimoto, H.,Sode, K.,Toyo'oka, T.,Todoroki, K.,Ikebukuro, K.; Development of a DNA aptamer that binds to the complementarity-determining region of therapeutic monoclonal antibody and affinity improvement induced by pH-change for sensitive detection.; Biosens.Bioelectron., 203:114027-114027, 2022; PubMed: 35114463; DOI: 10.1016/j.bios.2022.114027

実験手法

X-RAY DIFFRACTION (1.7 Å)