7V4P

Unique non-heme hydroxylase in biosynthesis of nucleoside antibiotic pathway uncover mechanism of reaction

Summary for 7V4P

• Entry DOI: 10.2210/pdb7v4p/pdb
• Descriptor: Beta-hydroxylase, FE (III) ION (3 entities in total)
• Functional Keywords: caprazamycin, mray, beta-hydroxylase, antibiotic
• Biological source: Streptomyces sp. MK730-62F2
• Total number of polymer chains: 2
• Total formula weight: 45546.84

Authors

Li, T.L.,Saeid, M.Z. (deposition date: 2021-08-13, release date: 2022-02-23, Last modification date: 2023-11-29)

• Primary citation: Zadeh, S.M.,Chen, M.H.,Wang, Z.C.,Astani, E.K.,Lo, I.W.,Lin, K.H.,Hsu, N.S.,Adhikari, K.,Lyu, S.Y.,Tsai, H.Y.,Terasawa, Y.,Yabe, M.,Yamamoto, K.,Ichikawa, S.,Li, T.L.; beta-Hydroxylation of alpha-amino-beta-hydroxylbutanoyl-glycyluridine catalyzed by a nonheme hydroxylase ensures the maturation of caprazamycin; Commun Chem, 5:87-, 2022; DOI: 10.1038/s42004-022-00703-6

Experimental method

X-RAY DIFFRACTION (1.95 Å)