7V3D

Complex structure of serine hydroxymethyltransferase from Enterococcus faecium and its inhibitor

7V3D の概要

• エントリーDOI: 10.2210/pdb7v3d/pdb
• 分子名称: Serine hydroxymethyltransferase, (4R)-6-azanyl-4-[3-(hydroxymethyl)-5-phenyl-phenyl]-3-methyl-4-propan-2-yl-1H-pyrano[2,3-c]pyrazole-5-carbonitrile, PYRIDOXAL-5'-PHOSPHATE, ... (5 entities in total)
• 機能のキーワード: inhibitor, antibacterial mechanism, complex, transferase
• 由来する生物種: Enterococcus faecium (Streptococcus faecium)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 91376.21

構造登録者

Hayashi, H.,Murayama, K. (登録日: 2021-08-10, 公開日: 2022-07-06, 最終更新日: 2023-11-29)

• 主引用文献: Makino, Y.,Oe, C.,Iwama, K.,Suzuki, S.,Nishiyama, A.,Hasegawa, K.,Okuda, H.,Hirata, K.,Ueno, M.,Kawaji, K.,Sasano, M.,Usui, E.,Hosaka, T.,Yabuki, Y.,Shirouzu, M.,Katsumi, M.,Murayama, K.,Hayashi, H.,Kodama, E.N.; Serine hydroxymethyltransferase as a potential target of antibacterial agents acting synergistically with one-carbon metabolism-related inhibitors.; Commun Biol, 5:619-619, 2022; PubMed: 35739195; DOI: 10.1038/s42003-022-03555-x

実験手法

X-RAY DIFFRACTION (2.28 Å)