7UYW

Crystal structure of JAK2 kinase domain in complex with compound 30

7UYW の概要

• エントリーDOI: 10.2210/pdb7uyw/pdb
• 分子名称: Tyrosine-protein kinase JAK2, 2-(2,6-difluorophenyl)-4-[4-(pyrrolidine-1-carbonyl)anilino]-5H-pyrrolo[3,4-b]pyridin-5-one (3 entities in total)
• 機能のキーワード: non-receptor tyrosine-protein kinase jak2, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34798.57

構造登録者

Toms, A.V.,Leit, S.,Greenwood, J.R.,Mondal, S.,Carriero, S.,Dahlgren, M.,Harriman, G.C.,Kennedy-Smith, J.J.,Kapeller, R.,Lawson, J.P.,Romero, D.L.,Shelley, M.,Wester, R.T.,Westlin, W.,Mc Elwee, J.J.,Miao, W.,Edmondson, S.D.,Massee, C.E. (登録日: 2022-05-07, 公開日: 2022-08-24)

• 主引用文献: Leit, S.,Greenwood, J.R.,Mondal, S.,Carriero, S.,Dahlgren, M.,Harriman, G.C.,Kennedy-Smith, J.J.,Kapeller, R.,Lawson, J.P.,Romero, D.L.,Toms, A.V.,Shelley, M.,Wester, R.T.,Westlin, W.,McElwee, J.J.,Miao, W.,Edmondson, S.D.,Masse, C.E.; Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of psoriasis.; Bioorg.Med.Chem.Lett., 73:128891-128891, 2022; PubMed: 35842205; DOI: 10.1016/j.bmcl.2022.128891

実験手法

X-RAY DIFFRACTION (2.51 Å)