7UXL

Crystal structure of malaria transmission-blocking antigen Pfs48/45-6C variant in complex with human antibodies RUPA-44 and RUPA-29

7UXL の概要

• エントリーDOI: 10.2210/pdb7uxl/pdb
• 分子名称: RUPA-44 Fab Kappa chain, RUPA-44 Fab Heavy chain, Gametocyte surface protein P45/48, ... (6 entities in total)
• 機能のキーワード: pfs48/45, human transmission-blocking antibodies, plasmodium falciparum, malaria, immune system
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 111470.65

構造登録者

Hailemariam, S.,Ivanochko, D.,Julien, J.P. (登録日: 2022-05-05, 公開日: 2023-02-15, 最終更新日: 2023-10-25)

• 主引用文献: Fabra-Garcia, A.,Hailemariam, S.,de Jong, R.M.,Janssen, K.,Teelen, K.,van de Vegte-Bolmer, M.,van Gemert, G.J.,Ivanochko, D.,Semesi, A.,McLeod, B.,Vos, M.W.,de Bruijni, M.H.C.,Bolscher, J.M.,Szabat, M.,Vogt, S.,Kraft, L.,Duncan, S.,Kamya, M.R.,Feeney, M.E.,Jagannathan, P.,Greenhouse, B.,Dechering, K.J.,Sauerwein, R.W.,King, C.R.,MacGill, R.S.,Bousema, T.,Julien, J.P.,Jore, M.M.; Highly potent, naturally acquired human monoclonal antibodies against Pfs48/45 block Plasmodium falciparum transmission to mosquitoes.; Immunity, 56:406-419.e7, 2023; PubMed: 36792574; DOI: 10.1016/j.immuni.2023.01.009

実験手法

X-RAY DIFFRACTION (2.86 Å)