7UWP

Detergent-bound CYP51 from Acanthamoeba castellanii

Summary for 7UWP

• Entry DOI: 10.2210/pdb7uwp/pdb
• Descriptor: sterol 14a-demethylase, PROTOPORPHYRIN IX CONTAINING FE, DODECYL-BETA-D-MALTOSIDE, ... (4 entities in total)
• Functional Keywords: cytochrome p450, cyp51, sterol 14 alpha- demethylase, sterol biosynthesis, oxidoreductase
• Biological source: Acanthamoeba castellanii
• Total number of polymer chains: 2
• Total formula weight: 107148.85

Authors

Hargrove, T.Y.,Wawrzak, Z.,Lepesheva, G.I. (deposition date: 2022-05-03, release date: 2023-04-12, Last modification date: 2024-05-01)

• Primary citation: Hargrove, T.Y.,Lamb, D.C.,Wawrzak, Z.,Hull, M.,Kelly, S.L.,Guengerich, F.P.,Lepesheva, G.I.; Identification of Potent and Selective Inhibitors of Acanthamoeba: Structural Insights into Sterol 14-Demethylase as a Key Drug Target; J.Med.Chem., 2024

Experimental method

X-RAY DIFFRACTION (1.95 Å)