7UW6

The co-crystal structure of low molecular weight protein tyrosine phosphatase (LMW-PTP) with a small molecule inhibitor SPAA-2

7UW6 の概要

• エントリーDOI: 10.2210/pdb7uw6/pdb
• 分子名称: Low molecular weight phosphotyrosine protein phosphatase, 2-[(1,3-benzothiazol-2-yl)amino]-2-oxoethane-1-sulfonic acid (3 entities in total)
• 機能のキーワード: low molecular weight protein tyrosine phosphatase; inhibitor; complex, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 20377.98

構造登録者

Wang, J.,Zhang, Z.Y. (登録日: 2022-05-02, 公開日: 2022-10-19, 最終更新日: 2023-10-18)

• 主引用文献: He, R.,Wang, J.,Yu, Z.H.,Moyers, J.S.,Michael, M.D.,Durham, T.B.,Cramer, J.W.,Qian, Y.,Lin, A.,Wu, L.,Noinaj, N.,Barrett, D.G.,Zhang, Z.Y.; Structure-Based Design of Active-Site-Directed, Highly Potent, Selective, and Orally Bioavailable Low-Molecular-Weight Protein Tyrosine Phosphatase Inhibitors.; J.Med.Chem., 65:13892-13909, 2022; PubMed: 36197449; DOI: 10.1021/acs.jmedchem.2c01143

実験手法

X-RAY DIFFRACTION (1.5 Å)