7UW0

Crystal structure of human ClpP protease in complex with TR-133

7UW0 の概要

• エントリーDOI: 10.2210/pdb7uw0/pdb
• 分子名称: ATP-dependent Clp protease proteolytic subunit, mitochondrial, 3-({3-[(4-bromophenyl)methyl]-4-oxo-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl}methyl)benzonitrile (3 entities in total)
• 機能のキーワード: agonist, apoptosis, proteolysis, imipridone, cancer, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 7
• 化学式量合計: 172306.34

構造登録者

Mabanglo, M.F.,Houry, W.A. (登録日: 2022-05-02, 公開日: 2023-01-11, 最終更新日: 2023-10-25)

• 主引用文献: Mabanglo, M.F.,Wong, K.S.,Barghash, M.M.,Leung, E.,Chuang, S.H.W.,Ardalan, A.,Majaesic, E.M.,Wong, C.J.,Zhang, S.,Lang, H.,Karanewsky, D.S.,Iwanowicz, A.A.,Graves, L.M.,Iwanowicz, E.J.,Gingras, A.C.,Houry, W.A.; Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome.; Structure, 31:185-, 2023; PubMed: 36586405; DOI: 10.1016/j.str.2022.12.002

実験手法

X-RAY DIFFRACTION (2.8 Å)