7UVF

Crystal structure of ZED8 Fab complex with CD8 alpha

Summary for 7UVF

• Entry DOI: 10.2210/pdb7uvf/pdb
• Descriptor: T-cell surface glycoprotein CD8 alpha chain, Immunoglobulin heavy chain, Immunoglobulin light chain, ... (6 entities in total)
• Functional Keywords: imaging, cd8, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 122837.79

Authors

Yu, C.,Davies, C.,Koerber, J.T.,Williams, S. (deposition date: 2022-05-01, release date: 2022-10-12, Last modification date: 2024-04-03)

Primary citation

Ogasawara, A.,Kiefer, J.R.,Gill, H.,Chiang, E.,Sriraman, S.,Ferl, G.Z.,Ziai, J.,Bohorquez, S.S.,Guelman, S.,Wang, X.,Yang, J.,Phan, M.M.,Nguyen, V.,Chung, S.,Yu, C.,Tinianow, J.,Waaijer, S.J.H.,De Crespigny, A.,Marik, J.,Boswell, C.A.,Zabka, T.,Staflin, K.,Williams, S.P.
Preclinical development of ZED8, an 89 Zr immuno-PET reagent for monitoring tumor CD8 status in patients undergoing cancer immunotherapy.
Eur J Nucl Med Mol Imaging, 50:287-301, 2023

PubMed Abstract: ZED8 is a novel monovalent antibody labeled with zirconium-89 for the molecular imaging of CD8. This work describes nonclinical studies performed in part to provide rationale for and to inform expectations in the early clinical development of ZED8, such as in the studies outlined in clinical trial registry NCT04029181 [1].

PubMed: 36271158
DOI: 10.1007/s00259-022-05968-6

Experimental method

X-RAY DIFFRACTION (2.6 Å)