7UVF

Crystal structure of ZED8 Fab complex with CD8 alpha

Summary for 7UVF

• Entry DOI: 10.2210/pdb7uvf/pdb
• Descriptor: T-cell surface glycoprotein CD8 alpha chain, Immunoglobulin heavy chain, Immunoglobulin light chain, ... (6 entities in total)
• Functional Keywords: imaging, cd8, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 122837.79

Authors

Yu, C.,Davies, C.,Koerber, J.T.,Williams, S. (deposition date: 2022-05-01, release date: 2022-10-12, Last modification date: 2024-04-03)

• Primary citation: Ogasawara, A.,Kiefer, J.R.,Gill, H.,Chiang, E.,Sriraman, S.,Ferl, G.Z.,Ziai, J.,Bohorquez, S.S.,Guelman, S.,Wang, X.,Yang, J.,Phan, M.M.,Nguyen, V.,Chung, S.,Yu, C.,Tinianow, J.,Waaijer, S.J.H.,De Crespigny, A.,Marik, J.,Boswell, C.A.,Zabka, T.,Staflin, K.,Williams, S.P.; Preclinical development of ZED8, an 89 Zr immuno-PET reagent for monitoring tumor CD8 status in patients undergoing cancer immunotherapy.; Eur J Nucl Med Mol Imaging, 50:287-301, 2023; PubMed: 36271158; DOI: 10.1007/s00259-022-05968-6

Experimental method

X-RAY DIFFRACTION (2.6 Å)