7UV9

KDM2A-nucleosome structure stabilized by H3K36C-UNC8015 covalent conjugate

7UV9 の概要

• エントリーDOI: 10.2210/pdb7uv9/pdb
• EMDBエントリー: 26809 26810
• 分子名称: Histone H3.2, Histone H4, Histone H2A type 1, ... (9 entities in total)
• 機能のキーワード: chromatin nucleosome lysine demethylase jmjc protein, gene regulation-dna complex, gene regulation/dna
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 11
• 化学式量合計: 302955.70

構造登録者

Spangler, C.J.,Skrajna, A.,Foley, C.A.,Budziszewski, G.R.,Azzam, D.N.,James, L.I.,Frye, S.V.,McGinty, R.K. (登録日: 2022-04-29, 公開日: 2023-02-22, 最終更新日: 2024-06-12)

• 主引用文献: Spangler, C.J.,Skrajna, A.,Foley, C.A.,Nguyen, A.,Budziszewski, G.R.,Azzam, D.N.,Arteaga, E.C.,Simmons, H.C.,Smith, C.B.,Wesley, N.A.,Wilkerson, E.M.,McPherson, J.E.,Kireev, D.,James, L.I.,Frye, S.V.,Goldfarb, D.,McGinty, R.K.; Structural basis of paralog-specific KDM2A/B nucleosome recognition.; Nat.Chem.Biol., 19:624-632, 2023; PubMed: 36797403; DOI: 10.1038/s41589-023-01256-y

実験手法

ELECTRON MICROSCOPY (3.2 Å)