7UUK

Crystal structure of aminoglycoside resistance enzyme ApmA, complex with tobramycin

7UUK の概要

• エントリーDOI: 10.2210/pdb7uuk/pdb
• 関連するPDBエントリー: 7UUJ 7UUL 7UUM 7UUN 7UUO
• 分子名称: Aminocyclitol acetyltransferase ApmA, TOBRAMYCIN, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: xat, xenobiotic acetyltransferase, left-handed beta helix, lbh, antibiotic resistance, aminoglycoside, structural genomics, csgid, center for structural genomics of infectious diseases, niaid, national institute of allergy and infectious diseases, transferase, center for structural biology of infectious diseases, csbid
• 由来する生物種: Staphylococcus aureus
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 95481.86

構造登録者

Stogios, P.J.,Evdokimova, E.,Di Leo, R.,Bordeleau, E.,Wright, G.D.,Savchenko, A.,Joachimiak, A.,Satchell, K.J.F.,Center for Structural Biology of Infectious Diseases (CSBID) (登録日: 2022-04-28, 公開日: 2023-04-19, 最終更新日: 2026-02-25)

• 主引用文献: Bordeleau, E.,Stogios, P.J.,Evdokimova, E.,Koteva, K.,Savchenko, A.,Wright, G.D.; Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance; Nat.Chem.Biol., 20:234-242, 2024; DOI: 10.1038/s41589-023-01483-3

実験手法

X-RAY DIFFRACTION (2.82 Å)