7UTB
KPC-2 CARBAPENEMASE IN COMPLEX WITH THE BORONIC ACID INHIBITOR MB_076
Summary for 7UTB
Entry DOI | 10.2210/pdb7utb/pdb |
Descriptor | Carbapenem-hydrolyzing beta-lactamase KPC, [(1~{R})-1-[2-[(5-azanyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethanoylamino]-2-(4-carboxy-1,2,3-triazol-1-yl)ethyl]-$l^{3}-oxidanyl-bis(oxidanyl)boron (3 entities in total) |
Functional Keywords | beta-lactamase, carbapenemase, inhibitor complex, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 1 |
Total formula weight | 28566.93 |
Authors | van den Akker, F.,Alsenani, T.A. (deposition date: 2022-04-26, release date: 2022-12-14, Last modification date: 2023-10-25) |
Primary citation | Alsenani, T.A.,Rodriguez, M.M.,Ghiglione, B.,Taracila, M.A.,Mojica, M.F.,Rojas, L.J.,Hujer, A.M.,Gutkind, G.,Bethel, C.R.,Rather, P.N.,Introvigne, M.L.,Prati, F.,Caselli, E.,Power, P.,van den Akker, F.,Bonomo, R.A. Boronic Acid Transition State Inhibitors as Potent Inactivators of KPC and CTX-M beta-Lactamases: Biochemical and Structural Analyses. Antimicrob.Agents Chemother., 67:e0093022-e0093022, 2023 Cited by PubMed: 36602311DOI: 10.1128/aac.00930-22 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.38 Å) |
Structure validation
Download full validation report