7USZ

Human DDAH-1, holo (Zn-bound) form

7USZ の概要

• エントリーDOI: 10.2210/pdb7usz/pdb
• 分子名称: N(G),N(G)-dimethylarginine dimethylaminohydrolase 1, ZINC ION, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: cardiovascular enzyme, proton pump inhibitors, esomeprazole, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 63055.81

構造登録者

Smith, C.A.,Ghebre, Y.T. (登録日: 2022-04-26, 公開日: 2022-05-11, 最終更新日: 2023-10-18)

主引用文献

Smith, C.A.,Ebrahimpour, A.,Novikova, L.,Farina, D.,Bailey, A.O.,Russell, W.K.,Jain, A.,Saltzman, A.B.,Malovannaya, A.,Prasad, B.V.V.,Hu, L.,Ghebre, Y.T.
Esomeprazole covalently interacts with the cardiovascular enzyme dimethylarginine dimethylaminohydrolase: Insights into the cardiovascular risk of proton pump inhibitors.
Biochim Biophys Acta Gen Subj, 1866:130149-130149, 2022

PubMed Abstract: Proton pump inhibitors (PPIs) are widely prescribed drugs for the treatment of gastroesophageal reflux disease (GERD). Several meta-analysis studies have reported associations between prolonged use of PPIs and major adverse cardiovascular events. However, interaction of PPIs with biological molecules involved in cardiovascular health is incompletely characterized. Dimethylarginine dimethylaminohydrolase (DDAH) is a cardiovascular enzyme expressed in cardiomyocytes, and other somatic cell types in one of two isotypes (DDAH1 and DDAH2) to metabolize asymmetric dimethylarginine (ADMA); a cardiovascular risk factor and competitive inhibitor of nitric oxide synthases (NOSs).

PubMed: 35472493
DOI: 10.1016/j.bbagen.2022.130149

実験手法

X-RAY DIFFRACTION (1.65 Å)