7USZ

Human DDAH-1, holo (Zn-bound) form

7USZ の概要

• エントリーDOI: 10.2210/pdb7usz/pdb
• 分子名称: N(G),N(G)-dimethylarginine dimethylaminohydrolase 1, ZINC ION, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: cardiovascular enzyme, proton pump inhibitors, esomeprazole, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 63055.81

構造登録者

Smith, C.A.,Ghebre, Y.T. (登録日: 2022-04-26, 公開日: 2022-05-11, 最終更新日: 2023-10-18)

• 主引用文献: Smith, C.A.,Ebrahimpour, A.,Novikova, L.,Farina, D.,Bailey, A.O.,Russell, W.K.,Jain, A.,Saltzman, A.B.,Malovannaya, A.,Prasad, B.V.V.,Hu, L.,Ghebre, Y.T.; Esomeprazole covalently interacts with the cardiovascular enzyme dimethylarginine dimethylaminohydrolase: Insights into the cardiovascular risk of proton pump inhibitors.; Biochim Biophys Acta Gen Subj, 1866:130149-130149, 2022; PubMed: 35472493; DOI: 10.1016/j.bbagen.2022.130149

実験手法

X-RAY DIFFRACTION (1.65 Å)