7URD
Human PORCN in complex with LGK974 and WNT3A peptide
Summary for 7URD
Entry DOI | 10.2210/pdb7urd/pdb |
EMDB information | 26709 |
Descriptor | Isoform 2 of Protein-serine O-palmitoleoyltransferase porcupine, Isoform 2 of Protein Wnt-3a peptide, 2C11 light chain, ... (9 entities in total) |
Functional Keywords | inhibitor-bound, substrate-bound, complex, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 110707.45 |
Authors | |
Primary citation | Liu, Y.,Qi, X.,Donnelly, L.,Elghobashi-Meinhardt, N.,Long, T.,Zhou, R.W.,Sun, Y.,Wang, B.,Li, X. Mechanisms and inhibition of Porcupine-mediated Wnt acylation. Nature, 607:816-822, 2022 Cited by PubMed: 35831507DOI: 10.1038/s41586-022-04952-2 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.92 Å) |
Structure validation
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