7UR3

Hsp90 alpha inhibitor

Summary for 7UR3

• Entry DOI: 10.2210/pdb7ur3/pdb
• Descriptor: Heat shock protein HSP 90-alpha, (5-fluoro-1,3-dihydro-2H-isoindol-2-yl){4-hydroxy-3-[(2S)-2-hydroxy-5-phenylpentan-2-yl]phenyl}methanone (3 entities in total)
• Functional Keywords: chaperone, hsp90, inhibitor, chaperone-inhibitor complex, chaperone/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 33919.73

Authors

Deng, J.,Peng, S.,Balch, M.,Matts, R. (deposition date: 2022-04-21, release date: 2022-12-28, Last modification date: 2023-10-25)

• Primary citation: Mishra, S.J.,Reynolds, T.S.,Merfeld, T.,Balch, M.,Peng, S.,Deng, J.,Matts, R.,Blagg, B.S.J.; Structure-Activity Relationship Study of Tertiary Alcohol Hsp90 alpha-Selective Inhibitors with Novel Binding Mode.; Acs Med.Chem.Lett., 13:1870-1878, 2022; PubMed: 36518703; DOI: 10.1021/acsmedchemlett.2c00327

Experimental method

X-RAY DIFFRACTION (1.6 Å)