7UPG

Tau Paired Helical Filament from Alzheimer's Disease incubated with EGCG for 3 hours

7UPG の概要

• エントリーDOI: 10.2210/pdb7upg/pdb
• 関連するPDBエントリー: 7UPE 7UPF
• EMDBエントリー: 26665
• 分子名称: Isoform Tau-F of Microtubule-associated protein tau, (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate (2 entities in total)
• 機能のキーワード: amyloid, fibril, alzheimer's, disease, disaggregant, protein fibril
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 10
• 化学式量合計: 463782.43

構造登録者

Seidler, P.M.,Murray, K.A.,Boyer, D.R.,Ge, P.,Sawaya, M.R.,Eisenberg, D.S. (登録日: 2022-04-15, 公開日: 2022-09-28, 最終更新日: 2024-06-12)

• 主引用文献: Seidler, P.M.,Murray, K.A.,Boyer, D.R.,Ge, P.,Sawaya, M.R.,Hu, C.J.,Cheng, X.,Abskharon, R.,Pan, H.,DeTure, M.A.,Williams, C.K.,Dickson, D.W.,Vinters, H.V.,Eisenberg, D.S.; Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro.; Nat Commun, 13:5451-5451, 2022; PubMed: 36114178; DOI: 10.1038/s41467-022-32951-4

実験手法

ELECTRON MICROSCOPY (3.8 Å)