7ULI

Apo HMG-CoA Reductase from Arabidopsis thaliana (HMG1)

これはPDB形式変換不可エントリーです。

7ULI の概要

• エントリーDOI: 10.2210/pdb7uli/pdb
• 分子名称: 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 (2 entities in total)
• 機能のキーワード: apo, oxidoreductase
• 由来する生物種: Arabidopsis thaliana (thale cress)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 63660.52

構造登録者

Haywood, J.,Bond, C.S. (登録日: 2022-04-05, 公開日: 2022-05-18, 最終更新日: 2023-10-18)

主引用文献

Haywood, J.,Breese, K.J.,Zhang, J.,Waters, M.T.,Bond, C.S.,Stubbs, K.A.,Mylne, J.S.
A fungal tolerance trait and selective inhibitors proffer HMG-CoA reductase as a herbicide mode-of-action.
Nat Commun, 13:5563-5563, 2022

PubMed Abstract: Decades of intense herbicide use has led to resistance in weeds. Without innovative weed management practices and new herbicidal modes of action, the unabated rise of herbicide resistance will undoubtedly place further stress upon food security. HMGR (3-hydroxy-3-methylglutaryl-coenzyme A reductase) is the rate limiting enzyme of the eukaryotic mevalonate pathway successfully targeted by statins to treat hypercholesterolemia in humans. As HMGR inhibitors have been shown to be herbicidal, HMGR could represent a mode of action target for the development of herbicides. Here, we present the crystal structure of a HMGR from Arabidopsis thaliana (AtHMG1) which exhibits a wider active site than previously determined structures from different species. This plant conserved feature enables the rational design of specific HMGR inhibitors and we develop a tolerance trait through sequence analysis of fungal gene clusters. These results suggest HMGR to be a viable herbicide target modifiable to provide a tolerance trait.

PubMed: 36137996
DOI: 10.1038/s41467-022-33185-0

実験手法

X-RAY DIFFRACTION (1.9 Å)