7ULC

Crystal structure of queuine salvage enzyme DUF2419 mutant D231N, in complex with queuosine-5'-monophosphate

Summary for 7ULC

• Entry DOI: 10.2210/pdb7ulc/pdb
• Related: 7U07
• Descriptor: Queuosine salvage protein DUF2419, 2-amino-5-({[(1S,4S,5R)-4,5-dihydroxycyclopent-2-en-1-yl]amino}methyl)-7-(5-O-phosphono-beta-D-ribofuranosyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, DI(HYDROXYETHYL)ETHER, ... (4 entities in total)
• Functional Keywords: 7-deazaguanine salvage, queuosine, trna modification, hydrolase
• Biological source: Sphaerobacter thermophilus DSM 20745
• Total number of polymer chains: 2
• Total formula weight: 75460.27

Authors

Hung, S.-H.,Swairjo, M.A. (deposition date: 2022-04-04, release date: 2022-12-21, Last modification date: 2023-10-25)

• Primary citation: Hung, S.H.,Elliott, G.I.,Ramkumar, T.R.,Burtnyak, L.,McGrenaghan, C.J.,Alkuzweny, S.,Quaiyum, S.,Iwata-Reuyl, D.,Pan, X.,Green, B.D.,Kelly, V.P.,de Crecy-Lagard, V.,Swairjo, M.A.; Structural basis of Qng1-mediated salvage of the micronutrient queuine from queuosine-5'-monophosphate as the biological substrate.; Nucleic Acids Res., 51:935-951, 2023; PubMed: 36610787; DOI: 10.1093/nar/gkac1231

Experimental method

X-RAY DIFFRACTION (1.99 Å)