7UKV

Wild type EGFR in complex with Lazertinib (YH25448)

7UKV の概要

• エントリーDOI: 10.2210/pdb7ukv/pdb
• 分子名称: Epidermal growth factor receptor, N-[5-{[(4P)-4-{4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl}pyrimidin-2-yl]amino}-4-methoxy-2-(morpholin-4-yl)phenyl]propanamide (3 entities in total)
• 機能のキーワード: cancer, drug discovery, kinase, transferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37947.87

構造登録者

Beyett, T.S.,Pham, C.,Eck, M.J.,Heppner, D.E. (登録日: 2022-04-02, 公開日: 2022-11-23, 最終更新日: 2023-10-25)

• 主引用文献: Heppner, D.E.,Wittlinger, F.,Beyett, T.S.,Shaurova, T.,Urul, D.A.,Buckley, B.,Pham, C.D.,Schaeffner, I.K.,Yang, B.,Ogboo, B.C.,May, E.W.,Schaefer, E.M.,Eck, M.J.,Laufer, S.A.,Hershberger, P.A.; Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448).; Acs Med.Chem.Lett., 13:1856-1863, 2022; PubMed: 36518696; DOI: 10.1021/acsmedchemlett.2c00213

実験手法

X-RAY DIFFRACTION (2.4 Å)