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7UKH

Human Kv4.2-KChIP2-DPP6 channel complex in an open state, intracellular region

7UKH の概要
エントリーDOI10.2210/pdb7ukh/pdb
EMDBエントリー26581
分子名称Potassium voltage-gated channel subfamily D member 2, Isoform 2 of Kv channel-interacting protein 2, ZINC ION, ... (4 entities in total)
機能のキーワードpotassium channel complex, membrane protein
由来する生物種Homo sapiens (human)
詳細
タンパク質・核酸の鎖数8
化学式量合計352841.84
構造登録者
Zhao, H.,Dai, Y.,Lee, C.H. (登録日: 2022-04-01, 公開日: 2022-06-29, 最終更新日: 2024-02-14)
主引用文献Ye, W.,Zhao, H.,Dai, Y.,Wang, Y.,Lo, Y.H.,Jan, L.Y.,Lee, C.H.
Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes.
Mol.Cell, 82:2427-, 2022
Cited by
PubMed Abstract: The voltage-gated ion channel activity depends on both activation (transition from the resting state to the open state) and inactivation. Inactivation is a self-restraint mechanism to limit ion conduction and is as crucial to membrane excitability as activation. Inactivation can occur when the channel is open or closed. Although open-state inactivation is well understood, the molecular basis of closed-state inactivation has remained elusive. We report cryo-EM structures of human K4.2 channel complexes in inactivated, open, and closed states. Closed-state inactivation of K4 involves an unprecedented symmetry breakdown for pore closure by only two of the four S4-S5 linkers, distinct from known mechanisms of open-state inactivation. We further capture K4 in a putative resting state, revealing how voltage sensor movements control the pore. Moreover, our structures provide insights regarding channel modulation by KChIP2 and DPP6 auxiliary subunits. Our findings elucidate mechanisms of closed-state inactivation and voltage-dependent activation of the K4 channel.
PubMed: 35597238
DOI: 10.1016/j.molcel.2022.04.032
主引用文献が同じPDBエントリー
実験手法
ELECTRON MICROSCOPY (2.33 Å)
構造検証レポート
Validation report summary of 7ukh
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-12-18に公開中

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