7UK1
Complex Structure of Human Polypyrimidine Splicing Factor (PSF/SFPQ) with Murine Virus-like 30S Transcript-1 (VS30-1) Reveals Cooperative Binding of RNA
Summary for 7UK1
Entry DOI | 10.2210/pdb7uk1/pdb |
Descriptor | Splicing factor, proline- and glutamine-rich, MAGNESIUM ION (3 entities in total) |
Functional Keywords | polypyridimine-binding splicing factor, 5'-polyuridine negative-sense (5'-pun) template, rna-dependent dna-binding regulation, dna-binding domain (dbd), rna-binding motif (rrm), vl30-1, allostery, cooperativity, splicing |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 95650.89 |
Authors | Lomakin, I.B.,Wang, J. (deposition date: 2022-03-31, release date: 2022-09-21, Last modification date: 2023-10-18) |
Primary citation | Wang, J.,Sachpatzidis, A.,Christian, T.D.,Lomakin, I.B.,Garen, A.,Konigsberg, W.H. Insight into the Tumor Suppression Mechanism from the Structure of Human Polypyrimidine Splicing Factor (PSF/SFPQ) Complexed with a 30mer RNA from Murine Virus-like 30S Transcript-1. Biochemistry, 61:1723-1734, 2022 Cited by PubMed: 35998361DOI: 10.1021/acs.biochem.2c00192 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
Download full validation report