7UK1

Complex Structure of Human Polypyrimidine Splicing Factor (PSF/SFPQ) with Murine Virus-like 30S Transcript-1 (VS30-1) Reveals Cooperative Binding of RNA

Summary for 7UK1

• Entry DOI: 10.2210/pdb7uk1/pdb
• Descriptor: Splicing factor, proline- and glutamine-rich, MAGNESIUM ION (3 entities in total)
• Functional Keywords: polypyridimine-binding splicing factor, 5'-polyuridine negative-sense (5'-pun) template, rna-dependent dna-binding regulation, dna-binding domain (dbd), rna-binding motif (rrm), vl30-1, allostery, cooperativity, splicing
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 95650.89

Authors

Lomakin, I.B.,Wang, J. (deposition date: 2022-03-31, release date: 2022-09-21, Last modification date: 2023-10-18)

• Primary citation: Wang, J.,Sachpatzidis, A.,Christian, T.D.,Lomakin, I.B.,Garen, A.,Konigsberg, W.H.; Insight into the Tumor Suppression Mechanism from the Structure of Human Polypyrimidine Splicing Factor (PSF/SFPQ) Complexed with a 30mer RNA from Murine Virus-like 30S Transcript-1.; Biochemistry, 61:1723-1734, 2022; PubMed: 35998361; DOI: 10.1021/acs.biochem.2c00192

Experimental method

X-RAY DIFFRACTION (2.7 Å)