7UK1

Complex Structure of Human Polypyrimidine Splicing Factor (PSF/SFPQ) with Murine Virus-like 30S Transcript-1 (VS30-1) Reveals Cooperative Binding of RNA

7UK1 の概要

• エントリーDOI: 10.2210/pdb7uk1/pdb
• 分子名称: Splicing factor, proline- and glutamine-rich, MAGNESIUM ION (3 entities in total)
• 機能のキーワード: polypyridimine-binding splicing factor, 5'-polyuridine negative-sense (5'-pun) template, rna-dependent dna-binding regulation, dna-binding domain (dbd), rna-binding motif (rrm), vl30-1, allostery, cooperativity, splicing
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 95650.89

構造登録者

Lomakin, I.B.,Wang, J. (登録日: 2022-03-31, 公開日: 2022-09-21, 最終更新日: 2023-10-18)

• 主引用文献: Wang, J.,Sachpatzidis, A.,Christian, T.D.,Lomakin, I.B.,Garen, A.,Konigsberg, W.H.; Insight into the Tumor Suppression Mechanism from the Structure of Human Polypyrimidine Splicing Factor (PSF/SFPQ) Complexed with a 30mer RNA from Murine Virus-like 30S Transcript-1.; Biochemistry, 61:1723-1734, 2022; PubMed: 35998361; DOI: 10.1021/acs.biochem.2c00192

実験手法

X-RAY DIFFRACTION (2.7 Å)