7UK1
Complex Structure of Human Polypyrimidine Splicing Factor (PSF/SFPQ) with Murine Virus-like 30S Transcript-1 (VS30-1) Reveals Cooperative Binding of RNA
7UK1 の概要
エントリーDOI | 10.2210/pdb7uk1/pdb |
分子名称 | Splicing factor, proline- and glutamine-rich, MAGNESIUM ION (3 entities in total) |
機能のキーワード | polypyridimine-binding splicing factor, 5'-polyuridine negative-sense (5'-pun) template, rna-dependent dna-binding regulation, dna-binding domain (dbd), rna-binding motif (rrm), vl30-1, allostery, cooperativity, splicing |
由来する生物種 | Homo sapiens (human) |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 95650.89 |
構造登録者 | |
主引用文献 | Wang, J.,Sachpatzidis, A.,Christian, T.D.,Lomakin, I.B.,Garen, A.,Konigsberg, W.H. Insight into the Tumor Suppression Mechanism from the Structure of Human Polypyrimidine Splicing Factor (PSF/SFPQ) Complexed with a 30mer RNA from Murine Virus-like 30S Transcript-1. Biochemistry, 61:1723-1734, 2022 Cited by PubMed: 35998361DOI: 10.1021/acs.biochem.2c00192 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.7 Å) |
構造検証レポート
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