Summary for 7UJO
| Entry DOI | 10.2210/pdb7ujo/pdb |
| Descriptor | Estrogen receptor, (9beta,11beta,17beta)-11-{4-[2-(dimethylamino)ethoxy]phenyl}estra-1,3,5(10)-triene-3,17-diol, MAGNESIUM ION, ... (4 entities in total) |
| Functional Keywords | alpha helical bundle, hormone, breast cancer, estrogen, transcription |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 4 |
| Total formula weight | 122555.50 |
| Authors | Hosfield, D.J.,Greene, G.L.,Fanning, S.W. (deposition date: 2022-03-31, release date: 2022-06-15, Last modification date: 2023-10-18) |
| Primary citation | Hosfield, D.J.,Weber, S.,Li, N.S.,Suavage, M.,Joiner, C.F.,Hancock, G.R.,Sullivan, E.A.,Ndukwe, E.,Han, R.,Cush, S.,Laine, M.,Mader, S.C.,Greene, G.L.,Fanning, S.W. Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells. Elife, 11:-, 2022 Cited by PubMed: 35575456DOI: 10.7554/eLife.72512 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.449 Å) |
Structure validation
Download full validation report
