7UJN
Structure of Human SAMHD1 with Non-Hydrolysable dGTP Analog
Summary for 7UJN
Entry DOI | 10.2210/pdb7ujn/pdb |
EMDB information | 26567 |
Descriptor | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, 2'-deoxyguanosine-5'-O-(1-thiotriphosphate) (2 entities in total) |
Functional Keywords | dntp triphosphatase, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 295500.62 |
Authors | Huynh, K.W.,Ammirati, M.,Han, S. (deposition date: 2022-03-31, release date: 2022-07-20, Last modification date: 2024-02-14) |
Primary citation | Orris, B.,Huynh, K.W.,Ammirati, M.,Han, S.,Bolanos, B.,Carmody, J.,Petroski, M.D.,Bosbach, B.,Shields, D.J.,Stivers, J.T. Phosphorylation of SAMHD1 Thr592 increases C-terminal domain dynamics, tetramer dissociation and ssDNA binding kinetics. Nucleic Acids Res., 50:7545-7559, 2022 Cited by PubMed: 35801923DOI: 10.1093/nar/gkac573 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.89 Å) |
Structure validation
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