7UJ8
Estrogen Receptor Alpha Ligand Binding Domain Y537S in Complex with 4-Hydroxytamoxifen
Summary for 7UJ8
Entry DOI | 10.2210/pdb7uj8/pdb |
Descriptor | Estrogen receptor, 4-HYDROXYTAMOXIFEN (3 entities in total) |
Functional Keywords | alpha helical bundle, hormone receptor, breast cancer, tamoxifen, activating mutation, transcription |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 60843.09 |
Authors | Hosfield, D.J.,Greene, G.L.,Fanning, S.W. (deposition date: 2022-03-30, release date: 2022-06-15, Last modification date: 2023-10-18) |
Primary citation | Hosfield, D.J.,Weber, S.,Li, N.S.,Suavage, M.,Joiner, C.F.,Hancock, G.R.,Sullivan, E.A.,Ndukwe, E.,Han, R.,Cush, S.,Laine, M.,Mader, S.C.,Greene, G.L.,Fanning, S.W. Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells. Elife, 11:-, 2022 Cited by PubMed: 35575456DOI: 10.7554/eLife.72512 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.385 Å) |
Structure validation
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