7UH8
Integrin alpha IIB beta3 complex with roxifiban (Mn/Ca)
Summary for 7UH8
Entry DOI | 10.2210/pdb7uh8/pdb |
Related | 7L8P 7THO 7U9V 7UBR 7UCY |
Descriptor | Integrin alpha-IIb heavy chain, MANGANESE (II) ION, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (14 entities in total) |
Functional Keywords | complex, inhibitor, blood clotting, cell adhesion, cell adhesion-inhibitor complex, cell adhesion/inhibitor |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 8 |
Total formula weight | 302844.87 |
Authors | Lin, F.-Y.,Zhu, J.,Zhu, J.,Springer, T.A. (deposition date: 2022-03-25, release date: 2022-08-17, Last modification date: 2024-10-02) |
Primary citation | Lin, F.Y.,Li, J.,Xie, Y.,Zhu, J.,Huong Nguyen, T.T.,Zhang, Y.,Zhu, J.,Springer, T.A. A general chemical principle for creating closure-stabilizing integrin inhibitors. Cell, 185:3533-3550.e27, 2022 Cited by PubMed: 36113427DOI: 10.1016/j.cell.2022.08.008 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.75002413567 Å) |
Structure validation
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