7UE7
PANK3 complex structure with compound PZ-3883
Summary for 7UE7
| Entry DOI | 10.2210/pdb7ue7/pdb |
| Descriptor | Pantothenate kinase 3, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ... (7 entities in total) |
| Functional Keywords | pank, substrate, complex, transferase, pantothenate kinase, inhibitor, activator |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 43142.77 |
| Authors | White, S.W.,Yun, M.,Lee, R.E. (deposition date: 2022-03-21, release date: 2023-03-29, Last modification date: 2024-10-09) |
| Primary citation | Tangallapally, R.,Subramanian, C.,Yun, M.K.,Edwards, A.,Sharma, L.K.,Yang, L.,Creed, K.,Wang, J.,Jackowski, S.,Rock, C.O.,White, S.W.,Lee, R.E. Development of Brain Penetrant Pyridazine Pantothenate Kinase Activators. J.Med.Chem., 67:14432-14442, 2024 Cited by PubMed: 39136313DOI: 10.1021/acs.jmedchem.4c01211 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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