7UCG

Structure of the DU422 SOSIP.664 trimer in complex with neutralizing antibody Fab fragments 10-1074 and BG24

7UCG の概要

• エントリーDOI: 10.2210/pdb7ucg/pdb
• EMDBエントリー: 26443
• 分子名称: Envelope glycoprotein gp41, 2-acetamido-2-deoxy-beta-D-glucopyranose, BG24 CDRH2-v2 Fab heavy chain, ... (10 entities in total)
• 機能のキーワード: broadly neutralizing antibody, bnab, hiv-1, cd4 binding site, vh1-2, vrc01-class, antiviral protein, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• タンパク質・核酸の鎖数: 18
• 化学式量合計: 534873.77

構造登録者

Barnes, C.O.,Bjorkman, P.J. (登録日: 2022-03-16, 公開日: 2022-08-17, 最終更新日: 2022-09-07)

• 主引用文献: Barnes, C.O.,Schoofs, T.,Gnanapragasam, P.N.P.,Golijanin, J.,Huey-Tubman, K.E.,Gruell, H.,Schommers, P.,Suh-Toma, N.,Lee, Y.E.,Cetrulo Lorenzi, J.C.,Piechocka-Trocha, A.,Scheid, J.F.,West Jr., A.P.,Walker, B.D.,Seaman, M.S.,Klein, F.,Nussenzweig, M.C.,Bjorkman, P.J.; A naturally arising broad and potent CD4-binding site antibody with low somatic mutation.; Sci Adv, 8:eabp8155-eabp8155, 2022; PubMed: 35960796; DOI: 10.1126/sciadv.abp8155

実験手法

ELECTRON MICROSCOPY (3.5 Å)